Troops overran a rebel town and were locked in a second day of fierce clashes around Damascus on Thursday, as Islamic states urged Syria's regime and its foes to hold "serious" talks to end the bloodshed.
Opposition leader Ahmed Moaz al-Khatib has offered to hold peace talks with Syria's Vice President Faruq al-Sharaa, but Damascus has so far ignored it and intensified its attacks on rebel bastions.
After a 16-day onslaught, troops retook Karnaz, a town on the strategic highway linking Damascus and Aleppo, said Rami Abdel Rahman of the Syrian Observatory for Human Rights.
"(Rebel) fighters withdrew from Karnaz, which they seized in December last year, after heavy fighting and regular forces regained control," he told AFP.
Clashes and heavy shelling were reported in rebel strongholds around the capital for a second day as the army pressed a major offensive that the Observatory said had killed at least 64 people on Wednesday.
Another six civilians -- three of them under 18 -- were killed on Thursday when mortar rounds slammed into a bus garage in the northeastern district of Qaboon.
"The army is determined to crush terrorism around the capital and big cities, and over the past several days it has launched a qualitative operation and killed dozens of terrorists who dreamt of attacking and entering Damascus," pro-regime newspaper Al-Watan wrote.
The Observatory, which relies on a network of sources for its information, also reported regime shelling and clashes along a southern highway of the capital.
"Rebels attacked an army checkpoint overlooking the highway and now there are fierce clashes there," Marwan, an employee at a restaurant in the southern district of Midan, told AFP.
The Observatory also reported the arrival of military reinforcements at Daraya, a southwestern Damascus suburb that the army has bombarded for months.
On the outskirts of the capital, troops pounded rebel positions across the east and in the south, the Observatory said, as clashes broke out around a military vehicle depot to the northeast.
These areas are among the strongest bastions of the rebellion against President Bashar al-Assad's regime, which is battling to suppress a revolt the UN says has killed more than 60,000 people.
The offer for peace talks by Khatib, who heads the umbrella opposition National Coalition, was welcomed by the US and the Arab League, but Assad's regime has so far ignored the initiative and key opposition faction the Syrian National Council has flatly rejected it.
Khatib has stepped up the pressure to engage in talks by setting the regime a deadline of Sunday to free all women held in Syrian prisons.
The Organisation of Islamic Cooperation, at the end of a two-day summit in Cairo, called for "serious dialogue" between the Coalition and regime officials open to political change and without blood on their hands.
Such dialogue should "pave the way for a transition that will allow the Syrian people to achieve their aspirations for democratic change," a spokesman for the 57-member OIC told AFP, citing a final declaration.
"The Syrian government is primarily responsible for the violence," said the statement, which urged the UN Security Council to "assume its responsibilities to end the violence and bloodshed."
Iran had "reservations about a passage or two" in the statement on Syria, outgoing OIC chief Ekmeleddin Ihsanoglu said. Iraq and Lebanon also expressed reservations about the text, according to a source close to delegates.
Egypt's President Mohamed Morsi said he discussed a "general framework" on ways to resolve the conflict with Turkey and Iran on the sidelines of the summit.
"The foreign ministers are working on transforming this general framework into principles and measures" to be announced "in the coming days within an Arab, Islamic and international framework," he said.
The summit was being held in the absence of Syria which the OIC suspended in August because of a bloody crackdown on anti-regime protests.