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The sports network's website reported that Mexico's undefeated Leo Santa Cruz vacated the crown in order to move up to the junior featherweight ranks, setting up Ceja and McDonnell, IBF championships chairman Lindsey Tucker said.
McDonnell, 26, has won 12 fights in a row since last losing back in 2008 and sports a record of 20-2 with one drawn and nine knockouts, but this would be the Yorkshireman's first world title chance.
Ceja, 24-0 with all but two wins by knockout, has fought seven times in the past 13 months, going past the sixth round only once, but he never had a bout outside his homeland.
Promoters will negotiate terms with a purse bid to follow if required.