A Vatican humanitarian delegation will travel to Jordan to meet with refugees from Syria and take part in a regional conference of Catholic charity Caritas starting on Tuesday, the Vatican said.
"The situation on a humanitarian level in (Syria) and the region as a whole has become untenable," the Vatican said in a statement on Monday.
"The winter is adding to this terrible toll for the sufferings of a people whose weakest and most vulnerable are the worst affected," it said.
The delegation will be led by the head of the Vatican's Cor Unum humanitarian affairs department, Cardinal Robert Sarah.
Sarah will also meet with Jordanian King Abdullah II.