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France centre Florian Fritz was on Friday ruled out of his country's final Six Nations match with Scotland at the Stade de France on Saturday.
The 29-year-old 29-times capped Toulouse star failed to recover from a left foot infection and has been replaced on the replacements bench by the uncapped Gael Fickou.
"Florian Fritz will not be fit for Saturday," said a French team spokesman.
"He has a blister that has infected his left foot. He has been replaced by Gael Fickou."
Fritz, who started the 13-13 draw with Ireland last Saturday, had been unable to train since last Monday.
Fickou, 18, had been called up for the pre-Six Nations preparations but has played for the Under-20 side during the tournament.
France need to beat Scotland to give themselvees a chance of avoiding their first wooden spoon since 1999 and their first in the Six Nations.
Revised team (kick-off 2000GMT)
Yoann Huget; Vincent Clerc, Mathieu Bastareaud, Wesley Fofana, Maxime Medard; Frederic Michalak, Morgan Parra; Louis Picamoles, Thierry Dusautoir (capt), Antonie Claassen; Yoann Maestri, Sebastien Vahaamahina; Nicolas Mas, Benjamin Kayser, Thomas Domingo.
Replacements: Guilhem Guirado, Vincent Debaty, Luc Ducalcon, Christophe Samson, Yannick Nyanga, Maxime Machenaud, Francois Trinh-Duc, Gael Fickou)