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South Africa won the toss and decided to bat in the fourth one-day international at Kingsmead on Thursday.
South Africa, who lead the five-match series 2-1, were without Faf du Plessis, who will miss the last two matches as well as the start of the Indian Premier League next month because of a back injury.
He was replaced by David Miller, who plays for the Durban-based Dolphins franchise.
Pakistan also made one change, with Imran Farhat replacing opening batsman Nasir Jamshed, in a day match starting in bright sunshine.
South Africa: AB de Villiers (capt, wkt), Graeme Smith, Hashim Amla, Colin Ingram, David Miller, Farhaan Behardien, Ryan McLaren, Robin Peterson, Rory Kleinveldt, Dale Steyn, Lonwabo Tsotsobe.
Pakistan: Misbah-ul-Haq (capt), Mohammad Hafeez, Imran Farhat, Younis Khan, Shoaib Malik, Kamran Akmal (wkt), Shahid Afridi, Saeed Ajmal, Junaid Khan, Wahab Riaz, Mohammad Irfan.
Umpires: Kumar Dharmasena (SRI), Shaun George (RSA)
TV umpire: Billy Bowden (NZL)
Match referee: Andy Pycroft (ZIM)