North Korea dramatically escalated its warlike rhetoric on Thursday, warning that it had authorised plans for nuclear strikes on targets in the United States.
"The moment of explosion is approaching fast," the North Korean military said, warning that war could break out "today or tomorrow".
Pyongyang's latest pronouncement came as Washington scrambled to reinforce its Pacific missile defences, preparing to send ground-based interceptors to Guam and dispatching two Aegis class destroyers to the region.
Tension was also high on the North's heavily fortified border with South Korea, after Kim Jong-Un's isolated regime barred South Koreans from entering a Seoul-funded joint industrial park on its side of the frontier.
In a statement published by the state KCNA news agency, the Korean People's Army general staff warned Washington that US threats would be "smashed by... cutting-edge smaller, lighter and diversified nuclear strike means".
"The merciless operation of our revolutionary armed forces in this regard has been finally examined and ratified," the statement said.
Last month, North Korea threatened a "pre-emptive" nuclear strike against the United States, and last week its supreme army command ordered strategic rocket units to combat status.
But, while Pyongyang has successfully carried out test nuclear detonations, most experts think it is not yet capable of mounting a device on a ballistic missile capable of striking US bases or territory.
Mounting tension in the region could however trigger incidents on the tense and heavily militarised border between North and South Korea.
The White House was swift to react to Pyongyang's latest "unhelpful and unconstructive threats".
National Security Council spokeswoman Caitlin Hayden said: "It is yet another offering in a long line of provocative statements that only serve to further isolate North Korea from the rest of the international community and undermine its goal of economic development.
"North Korea should stop its provocative threats and instead concentrate on abiding by its international obligations."
US Defense Secretary Chuck Hagel earlier said Pyongyang represented a "real and clear danger" to the United States and to its allies South Korea and Japan.
"They have nuclear capacity now, they have missile delivery capacity now," Hagel said after a strategy speech at the National Defense University. "We take those threats seriously, we have to take those threats seriously.
"We are doing everything we can, working with the Chinese and others, to defuse that situation on the peninsula."
The Pentagon said it would send ground-based THAAD missile-interceptor batteries to protect military bases on the island of Guam, a US territory some 3,380 kilometres (2,100 miles) southeast of North Korea and home to 6,000 American military personnel, submarines and bombers.
They would complement two Aegis anti-missile destroyers already dispatched to the region.
The THAAD (Terminal High Altitude Area Defence) is a truck-mounted system that can pinpoint an enemy missile, track the projectile and launch an interceptor to bring it down.
The new defensive measures came as Pyongyang stopped South Korean staff members from entering the Kaesong complex, a shared industrial zone funded by Seoul but 10 kilometres inside the North.
Pyongyang said the 861 South Koreans already in the zone could leave.
The move cut the last practical cooperation between the rival powers and was seen as a dramatic escalation in the crisis.
South Korea's defence ministry said it had contingency plans that included "military action" if the safety of its citizens in Kaesong was threatened.
China, the North's sole major ally, appealed for "calm" from all sides, and Russia's Deputy Foreign Minister Igor Morgulov said he was worried the situation could spiral out of control.
Describing the Kaesong ban as "very regrettable", South Korea's Unification Ministry urged the North to normalise access immediately.
Around 53,000 North Koreans work at 120 South Korean plants at the complex, which was still operating normally Wednesday.
Tensions have soared on the Korean peninsula since December, when the North test launched a long-range rocket. In February, it upped the ante once again by conducting its third nuclear test.
Washington has deployed nuclear-capable US B-52s, B-2 stealth bombers and two US destroyers to South Korean air and sea space.
This week, the North warned it would reopen its mothballed Yongbyon reactor -- its source of weapons-grade plutonium. It was closed in July 2007 under a six-nation aid-for-disarmament accord.
The US-Korea Institute at John Hopkins University said Wednesday that a satellite photograph seen on March 27 appeared to show construction work along a road and near the back of the reactor was already under way.
Experts said it would take at least six months to get the reactor back up and running, after which it will be able to produce one bomb's worth of weapons-grade plutonium per year.