US stocks open mixed after Tuesday's surge

US stocks were mixed in opening trade Wednesday after Tuesday's one percent-plus gains, with trade tempered by Apple's fall in profits and a poor read on durable goods orders in March.

Five minutes into trade, the Dow Jones Industrial Average was up 21.81 points (0.15 percent) at 14,741.27.

The broad-based S&P 500 added 2.26 (0.14 percent) to 1,581.04, while the tech-rich Nasdaq Composite Index lost 1.64 (0.05 percent) to 3,267.69.