Australian Cameron Meyer won the opening 8.1km time-trial around Quito at the Tour of Switzerland on Saturday.
The Garmin rider beat Dutchman Niki Terpstra by 10 seconds in the Tour de France warm-up event.
Gusty winds hampered later starters on the course, notably time-trial specialist Fabian Cancellara, who finished 16th, losing 22sec.
Last year's winner Rui Costa of Portugal finished 40sec back, 5sec ahead of American contender Tejay Van Garderen.
Sunday's second stage takes the peloton over 119km from Ulrichen to the Crans-Montana ski station.