The UN's cultural organisation on Thursday urged Syria's regime and rebels to spare multi-millennial heritage that is being ravaged by shelling, theft and illegal digs.
"I urge all parties to take the necessary measures to prevent further damage to this heritage, which is among the most precious in the Islamic world," UNESCO chief Irina Bokova said.
"The protection of heritage is not a political issue," she told reporters after a meeting of experts held in Paris and attended by UN special envoy for Syria Lakhdar Brahimi.
The meeting took place as Western powers were mulling military action against the regime of Syrian President Bashar al-Assad over alleged chemical weapons use in deadly attacks last week.
More than two and a half years after Syria's crisis erupted, the UN body says it has a fairly clear picture of the extent of the damage inflicted to the country's many historical sites.
In late June, it had listed Syria's World Heritage sites as being in danger, in a bid to "mobilise all possible support for the safeguarding of these properties which are recognised by the international community as being of outstanding universal value for humanity as a whole."
The sites are the ancient cities of Damascus, Aleppo, Bosra, the "dead cities" of northern Syria as well as the Krak des Chevaliers and Salah el-Din castles and Palmyra Oasis.
Damascus and Aleppo are among the world's oldest continuously inhabited cities and the Krak des Chevaliers is considered the best-preserved Crusader castle.
Beyond the damage inflicted to Syria's historical sites by air raids, shelling and gunfire, the UN cultural body expressed concern over widespread theft of artefacts and rogue excavations.
"The trafficking is organised by powerful groups. We're talking about organised crime," UNESCO expert Francesco Bandarin said.
"You can already find stolen artefacts in Beirut. On some markets, there is a real influx," he said, adding that there had been recent precedents during the conflicts in Iraq, Libya and Mali.
Artefacts that have been dug up in illegal excavations are of particular concern because, unlike items displayed in museums, they have never been referenced.
"In such cases the damage is irreparable," he said.
According to a report submitted to UNESCO by Syria's antiquities chief Maamun Abdulkarim, dozens of sites have been affected, particularly in the regions of Aleppo, Idlib, Apamea, Deir Ezzor, Raqqa and Deraa.
Abdulkarim, a regime official whose department is part of the Syrian ministry of culture, said "the museums of Aleppo, Deir Ezzor, Hamas, Homs and Maaret al-Numan were targeted during the fighting."
Some of the main stolen artefacts he listed were an Aramaic gold-plated bronze statue dating to the 8th century BC, pottery from the Jaabar citadel in the central Raqqa region, daggers and other items from the Aleppo museum.