Minnows Ethiopia eliminated South Africa from the World Cup Africa zone qualifying competition Saturday by fighting back to defeat Central African Republic 2-1 in Congo.
The 'Walias Antelopes' topped Group A with 13 points, two more than 2010 World Cup hosts South Africa, whose 4-1 home win over Botswana in Durban proved futile.
Ethiopia, the bottom seeds in a mini-league expected to be dominated by South Africa, join Algeria, Egypt, Ghana and Ivory Coast in the two-leg play-offs.
Another four group winners will emerge later Saturday with Congo Brazzaville needing an away win and Nigeria, Senegal and Tunisia home draws to ensure progression.
Cameroon host Libya Sunday and a win for either country would take them through to the final round with the draw scheduled for September 16 in Cairo.
"Not qualifying for the final round is a huge personal disappointment," admitted South Africa coach Gordon Igesund, "but I am thrilled with the display."
Igesund, a highly successful domestic coach with four Premiership titles, succeeded sacked Pitso Mosimane after draws with Ethiopia and Botswana.
He led a much-changed team to three victories, but they lost 2-1 away to Ethiopia last June in what proved to be the group decider.
Defeat casts Bafana Bafana (The Boys) into limbo with their next competitive outing only in September 2014 when Africa Cup of Nations qualifiers kick off.
Minyahel Teshome was an ironic 61st-minute match-winner for Ethiopia in a match switched from Bangui to Brazzaville because of post-C.A.R. coup security concerns.
Teshome played in an away win over Botswana when suspended, resulting in Ethiopia being docked three points and having their qualification put on hold.
Central African Republic, out of the reckoning after four losses in a row, took the lead when Salif Keita scored midway through the opening half in the Congolese capital.
After both goalkeepers made outstanding late opening-half saves, Salahdin Ahmed levelled three minutes into the second half to turn the tide.
South Africa outplayed Botswana for long periods and deserved to lead by more than 2-0 at half-time with Botswana goalkeeper Kabelo Dambe making several excellent saves.
Kermit Erasmus put Bafana Bafana in front on 28 minutes with a far-post header and Dean Furman added a second with a close-range shot in stoppage time.
A powerful Jerome Ramatlhakwane header 18 minutes from time offered Botswana hope only for Bernard Parker to bag a late brace, with one goal coming off a penalty.