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Peyton Manning remained unbeaten in his NFL rivalry against younger brother Eli, throwing for 307 yards and two touchdowns Sunday to lead Denver over the New York Giants 41-23.
As their ex-NFL quarterback father Archie Manning watched, Peyton took his third triumph in as many tries over Eli, although the elder sibling's first two came when he played for Indianapolis instead of the Broncos.
"I think both of us are glad that it's over with," Peyton Manning said. "Not many other players have to go through it, so you can't ask too many people for advice. It's strange circumstances. Good team win -- just a unique situation."
Denver's Manning completed 30-of-43 passes while teammate Knowshon Moreno ran for touchdowns of 20 and 25 yards and Trindon Holliday returned a punt 81 yards for a touchdown for the visiting Broncos.
Eli Manning, who has two Super Bowl titles to only one for Peyton, went 28-of-49 for 362 yards but was picked off four times after being intercepted only 15 times in all of last season.
Peyton, five years older than Eli at 37, expressed doubt that he will see another brother matchup unless it comes in the Super Bowl.
"Post-season is one thing, but I don't think I will make it to the next regular season one," he said.
At Seattle, a severe lightning storm caused a one-hour delay in the first quarter, but the host Seahawks shook off the unexpected stoppage to rout San Francisco 29-3, with Marshawn Lynch running for two touchdowns and catching a pass for another.
Super Bowl Most Valuable Player Joe Flacco missed the birth of his second child to spark reigning NFL champion Baltimore to a 14-6 home victory over Cleveland.
Flacco's wife, Dana, gave birth to the couple's second son about an hour before the kickoff. Flacco, who signed a six-year deal worth $120.6 million in March, was told as he was warming up for the contest.
Flacco completed 22-of-33 passes for 211 yards, including a five-yard touchdown pass to Marlon Brown, and Bernard Pierce scored on a 5-yard touchdown run as the Ravens beat Cleveland for the 11th time in a row.
Aaron Rodgers matched a Matt Flynn's one-game record with 480 passing yards, completing 34-of-42 throws, including four for touchdowns in Green Bay's 38-20 rout of visiting Washington.
Rookie E.J. Manuel flipped a touchdown pass to Stevie Johnson with two seconds remaining to give host Buffalo a 24-23 victory over Carolina while Martellus Bennett caught a touchdown pass with 10 seconds to play to give host Chicago a 31-30 triumph over Minnesota.
Nick Novak kicked the winning field goal with seven seconds remaining to lift San Diego over host Philadelphia 33-30. Philip Rivers completed 36-of-47 passes for 419 yards and three touchdowns for San Diego.
The Kansas City Chiefs improved to 2-0 under new coach Andy Reid, matching their win total for all of last season, by edging Dallas 17-16.
Matt Ryan connected on 33-of-43 throws for 374 yards and a pair of touchdowns, with Julio Jones catching 11 of them for 182 yards, as Atlanta downed St. Louis 31-24.
Houston's Matt Schaub threw for 298 yards and three touchdowns, the last a one-yard flip to DeAndre Hopkins, to give host Houston a 30-24 overtime victory over Tennessee.
Garrett Hartley's 27-yard field goal with five seconds to play put New Orleans past Tampa Bay 16-14. The Buccaneers took the lead on Mason Foster's 85-yard interception return touchdown but Drew Brees, who threw for 322 yards, drove the Saints into position for the decisive kick.
Miami stayed unbeaten with a 24-20 triumph at Indianapolis as Ryan Tannehill threw for 319 yards and a touchdown and Mike Wallace, who went public with his unhappiness at not seeing the ball more after a one-catch Dolphins debut, made nine catches for 115 yards and a touchdown.
Rashard Mendenhall's late one-yard touchdown run gave host Arizona a 25-21 victory over Detroit. Carson Palmer threw for 248 yards and a touchdown for the Cardinals.
Sebastian Janikowski kicked four field goals and Marcel Reece ran for Oakland's only touchdown to power the Raiders over visiting Jacksonville 19-9.