Reigning Guangzhou Open champion Hsieh Su-Wei of Taiwan failed to make the quarter-finals at this year's event, crashing out Wednesday to her unseeded opponent.
Sixth-seeded Hsieh lost her second-round match against China's Zhang Shuai 6-2, 6-2 in little over one hour 15 minutes.
Hsieh's disappointing exit follows a golden year for the world number 42, who was crowned women's doubles Wimbledon champion earlier this year.
She remains in the doubles competition in Guangzhou, where she is the top seed with her partner, China's Peng Shuai.
Meanwhile, France's Alize Cornet beat Karolina Pliskova of the Czech Republic in her second-round match after an early scare.
The number two seed was taken to a tie-break in the first set, but won it 7/4 before dominating the second set and taking it to love.
Cornet will play Yvonne Meusburger next following the Austrian's 2-6, 6-2, 6-4 victory over Serbia's Vesna Dolonc.
Also through to the quarter-finals are China's Zheng Jie, who claimed victory over Hungary's Timea Babos 7-5, 7-6 (7/1), and Vania King of the US, who won her clash with Serbia's Bojana Jovanovski 6-4, 0-6, 6-4.
Eighth seed Monica Puig overcame Galina Voskoboeva of Kazakhstan 6-3, 6-2.
British number one Laura Robson and her compatriot Johanna Konta were in action in the evening session Wednesday. Both were to face Chinese opposition, with Robson meeting Zheng Saisai and Konta playing Peng Shuai for a place in the quarter-finals.