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Romania face Greece in the 2014 World Cup play-off without key defender Vlad Chiriches after the influential Tottenham back suffered an injury in his club's 1-0 home deefeat to Newcastle in the Premier League on Sunday.
"Chiriches will miss both legs of the play-off," the Romanian Football Federation confirmed on Monday.
Romania coach Victor Piturca plans to replace the absent 23-year-old with Dragos Grigore of Dinamo Bucharest.
Romania and Greece clash for a place at the World Cup ip Brazil next year on Friday and on November 9.