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Indonesia's birth control pill for men

While US progress lags, Indonesia readies male contraception pill.

Indonesia birth control men 2011 02 25 0Enlarge
A man from the Indonesian island Papua on March 10, 2010. (Michael Kappeler/AFP/Getty Images)

BANGKOK, Thailand — On the remote Indonesian island of Papua, tribesmen have long noticed the curious effect of a shrub called “gandarusa.”

If you chew its leaves often enough, men say, your wife won’t get pregnant.

Indonesian scientists, who have transferred this folk method from the jungle to the lab, claim they can extract the shrub’s active ingredient and mass produce it as an over-the-counter pill.

If they’re right, they will accomplish what Western pharmaceutical giants have researched but failed to deliver for decades: a birth control pill for men.

“With luck, it could be released late this year, but it will probably be sold in stores early next year,” said Sugiri Syarief, the head of Indonesia’s state-run National Family Planning Coordination Board.

Researchers began analyzing gandarusa in 1988, Sugiri said. Animal and human trials began in the 1990s and the plant’s effective compound was patented in 2007.

According to a government report on the drug, it prevents pregnancy by slowing down the activity of certain enzymes in the sperm that help them wriggle into a female’s ovum.

Researchers have tested the pill on two waves of male volunteers: first 36 men, then 120 men. This year, they’ll conduct a 350-man study to reinforce their findings so far: that trial volunteers’ sperm remains healthy but unable to penetrate a woman’s egg.

Men taking the gandarusa pills typically regain the ability to impregnate after 72 days, Sugiri said. “There are no side effects,” he said, though his study notes that some men experienced a boosted sex drive.

How did a far-less developed nation beat the Western world to this breakthrough? And for only $226,000, the amount Sugiri estimates his agency has spent on the project?

Bio-diversity deserves some credit. Indonesia is a lush and fertile archipelago, home to the world’s fourth-largest population and an estimated 7,000 medicinal plants. Potential benefits derived from this diverse range of flora are constantly undergoing study.

But the larger impasse to male birth control pills has been pharmaceutical giants, said Elaine Lissner, director of the non-profit Male Contraception Information Project in San Francisco.

Global demand for male birth control appears high, with a 2005 German survey revealing that 60 percent of men in Spain, Germany, Mexico and Brazil are willing to use a new male contraceptive.

But pouring millions into developing a birth control pill for guys still isn’t attractive as a business decision, Lissner said.

A recent study by the U.S. government’s Centers for Disease Control and Prevention indicated that more than 80 percent of women who’ve ever had sex with a man used birth control pills at some point. A male birth control pill could eat into this massive market. And because other options already exist — condoms and vasectomies — the male birth control pill would need to sell for a relatively cheap price.

German pharmaceutical firm Schering dropped male birth control research projects five years ago. Many other drug companies have done the same. A report authored by Lissner notes that, for decades, pundits have promised a male hormonal birth control method will arrive “in five to 10 years.”

“It’s a nightmare from the ‘for-profit’ standpoint,” Lissner said. “We have to accept that the needs of for-profit entities and the needs of the public don’t always perfectly match.”

Research into the gandarusa pill, however, is backed by a different motive: population control.