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Rosen, a Democratic strategist, said Romney shouldn't be talking about the economy's toll on women.
Ann Romney is fighting back after a Democratic consultant suggested the wife of wealthy Republican presidential candidate Mitt Romney shouldn't be talking about women and the economy because "she hasn't worked a day in her life."
"She's never really dealt with the kinds of economic issues that a majority of women in this country are facing," Hilary Rosen said in an appearance on CNN's "Anderson Cooper 360."
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The remark inspired Ann Romney's debut on Twitter, The Associated Press reported.
"I made a choice to stay home and raise five boys," she wrote. "Believe me, it was hard work."
The exchange sparked a spat by tweet, with President Barack Obama's advisers taking the rare step of siding with the spouse of his likely Republican opponent and demanding an apology from Rosen, who as of Thursday morning had not backed off, according to the AP.
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Rosen did later tweet: "Please know, I admire you. But your husband shouldn't say you are his expert on women and the economy," The Atlantic reported.
She also published a blog to The Huffington Post that attempted to explain the reasoning behind her comments on CNN, insisting "I have nothing against Ann Romney" and that she "admire[s] her grit in talking about her illness publicly," a reference to Ann's struggle with multiple sclerosis.
Romney senior adviser Eric Fehrnstrom called Rosen an "Obama adviser" and said her "new kill Ann strategy" had insulted working moms, CBS News reported.