A suspected US drone strike killed seven in northwestern Pakistan on Friday night.
In the first drone attack since Nawaz Sharif took over as the country's prime minister and demanded they come to an end, two missiles hit a compound in a village in the North Waziristan tribal area, near the Afghanistan border.
Many Pakistanis oppose US drone strikes, saying they kill a large number of innocent civilians and breed more extremism by those looking for retribution, which the US has denied.
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"We respect the sovereignty of others, but others don't respect our sovereignty. These daily drone attacks must stop," Sharif said when he was sworn in on Wednesday.
Friday's attack is the second since President Barack Obama spoke in late May of making changes and creating a new balance of priorities in the US fight against terrorism. He promised an emphasis on capturing suspects instead of killing them.
"America is at a crossroads. We must define the nature and scope of this struggle, or else it will define us," Obama said, "mindful of James Madison's warning that 'No nation could preserve its freedom in the midst of continual warfare.'"
Obama also noted that military missions like the one that resulted in Osama bin Laden's death "cannot be the norm."