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Vote expected to show waning support for President Mahmoud Ahmedinejad.
State-run Press TV said 130 candidates are competing for 65 seats in Iran's 290-member parliament, a largely symbolic body with little control over policy but influence in domestic matters.
More from GlobalPost: Iran: What the parliamentary elections mean
Polls opened this morning in 33 constituencies, and the country's Supreme Leader, Ayatollah Seyyed Ali Khamenei, has already cast his vote, said Press TV.
Ahmadinejad's opponent secured a comfortable majority of seats of the new parliament in the first round, said AP.
Reformist candidates are mainly suppressed, so today's vote is being seen mainly as a contest between those loyal to Ahmadinejad and those loyal to Khamenei, part of a growing divide in Iran's powerful clerical establishment, said Reuters.
Although Khamenei endorsed Ahmadinejad's 2009 presidential bid -- a disputed vote that led to mass riots and accusations of fraud from now-suppressed opposition leaders Mir-hossein Mousavi and Mehdi Karoubi -- relations have since devolved into a thinly-veiled struggle for power.