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At least 20 more people were injured, and many more evacuated from their homes in the provincial capital Birjand.
A 5.5 magnitude earthquake struck Iran Wednesday, leaving at least five people dead and 20 more injured.
Many in the province's capital of Birjand also evacuated their homes.
Mohammad Ali Akhoundi, head of South Khorasan province's crisis management service, said that at least five villages in the area were "destroyed or damaged" in the earthquake.
Search and rescue teams had been dispatched to the area, which is currently without communication, Agence France Presse reported.
This is the latest in a series of fatal quakes in Iran, a country located on major fault lines, Reuters reported. A 6.6 magnitude quake in 2003 destroyed the city of Bam and left over 25,000 dead, and a more recent pair of temblors in August killed more than 300 people in the country's northwest.
More from GlobalPost: Iran earthquake: 306 dead, over 3,000 injured — officials