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Turkey was an ally of Bashar al-Assad before the Syria's uprising began in early 2011.
Turkey on Wednesday announced it had expelled all of Syria's diplomatic staff in the country. Syrian envoys have 72 hours to leave Turkey, the Guardian reported.
The paper called the move the "most significant" in a series of diplomatic maneuvers meant to demonstrate distress over a weekend massacre over over 100 civilians, many of them children, in the Syrian city of Houla.
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"It is out of the question for us to remain silent and not respond to this action which constitutes a crime against humanity," the statement announcing the expulsion said. Agence France Presse reported that consular staff in Istanbul, Turkey's largest city, would not be affected.
By Wednesday, 13 countries had announced the expulsion of some or all of Syria's diplomatic staff in their countries in a coordinated effort to protest the Houla massacre. The United States, Australia, Japan, Britain, France, Germany, Italy, and Spain were among the countries that took action.
On Friday, the United Nations' top human rights body will meet to discuss the Houla massacre, according to the Associated Press.
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