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DL Ray McDonald (ankle) was ruled out of the New Orleans game.
TE Vernon Davis (concussion) was listed as questionable Friday after taking part in limited practice.
S Eric Reid (concussion) was listed as questionable Friday after taking part in limited practice for the third consecutive game.
WR Mario Manningham (knee) was a limited participant in practice Friday and listed as questionable, although he's expected to play at New Orleans.
TE Garrett Celek (hamstring) was listed as doubtful on Friday's injury report.
DL Justin Smith (shoulder) was listed as probable for the Saints game.
WR Michael Crabtree (Achilles) worked on running routes, sprinting and getting back into football shape this week in what head coach Jim Harbaugh called a "controlled environment." He is not expected to play against New Orleans on Sunday but could return to the active roster next week.