Madonna blows up at cigarette-smoking fans in Chile (VIDEO)

The anti-smoking Material Girl performs in Colombia on November 28.

Madonna threatened to cancel a show in the Chilean capital Santiago on Wednesday over cigarette-smoking fans.

The Material Girl blew up at fans granted access to a sound check at the open-air Estadio Nacional for smoking in her vicinity, according to The Hollywood Reporter.

"There are people smoking right now, " the singer said, according to celebrity gossip website TMZ.

"No smoking!"

"If you're going to smoke cigarettes, I'm not doing a show.

"You don't care about me? I don't care about you. All right? Are we going to play that game? I'm not kidding. I can't sing if you smoke… Entiendes?

"You're looking right at me and smoking cigarettes, like I'm a stupid f**king idiot."

Madge has a long history of upsetting her fans.

In October, she was accused of being insensitive to the Colorado community after she brandished a run onstage at a Denver concert three months after a massacre at a local theater.