AsianetApril 9, 2013 16:03
A University of Colorado Cancer Center study has described for the first time a switch that regulates the production of the protein E-Cadherin, the loss of which is a prerequisite for prostate cancer metastasis.The transcription factor SPDEF turns on and off production, leading to metastasis or stopping it cold in models of prostate cancer.“When E-Cadherin is lost, cells become ‘rouge‘ - they can detach from their surrounding tissues, move effortlessly through the circulatory system, grow and attach at new sites,” said Hari Koul, PhD, investigator at the CU Cancer Center and
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